Introduction:
The novel SARS-CoV-2 coronavirus identified in 2019 is the causative agent of the COVID-19 disease a globalrnpandemic. COVID-19 has not only devastated peoples health and relationships but their livelihoods as well. Indeed it hasrnbecome a threat to the world economy. Globally as of January 2022 over 300 million people have been infected resulting inrnover 5.4 million deaths. Kenya has reported over 306000 cases and at least 5411 deaths as at 6 January 2022. Although severalrnvaccines and two drugs are currently approved for the management of COVID-19 optimal management of the disease is stillrnelusive and therefore additional therapeutic alternatives are urgently required. Natural products offer a viable approach for therndevelopment of novel COVID-19 remedies not just in and for resource poor settings but on a global scale.
Objectives:
NOT STATED
Methodology:
In the current study medicinal plants with previously reported antioxidant anti-inflammatory immunomodulatoryrnantiviral antibacterial antioxidant and antiproliferative activities were processed and formulated safety profile evaluated throughrnmicrobial contamination and cytotoxicity analyses using In vitro methods and anecdotal data on effectiveness in COVID-19rntreatment collected n30. Structures of the constituent compounds present in the herbal combination remedy were elucidatedrnspectroscopically. In silico molecular docking was undertaken to decipher the binding affinities of the constituent compounds ontornselected putative targets.
Findings:
Results:
A combination of extracts of key medicinal plants/herbs targeting COVID-19 and associated predisposing ailmentsrnshowed a cytotoxicity value of CC50 573.462 g/ml and zero microbial contamination. Anecdotal data collected so far hasrnrevealed effectiveness of the combination herbal remedy in the treatment of COVID-19. Several constituent compounds exhibitedrnstrong binding affinities with docking scores 8.5 kcal/mol.
Conclusion:
Anecdotal evidence n 30 has revealed the effectiveness of the combination herbal remedy for the treatment ofrnCOVID-19. Additionally preliminary in vitro analysis has shown that the remedy is safe.
Publication Information
Author(s):
Focus County(s):
National
Programme Area(s):
Natural Products Research & Drug Development (NAPREDA)
Research Priority Area(s):
Disease Domain(s):
COVID 19
Document History:
Publication Date:
01.Jan.1970
Conference Title:
KASH CONFERENCE
Venue:
KASH 12