Cotrimoxazole Prophylaxis Impact On Cd4 Cells Infection Reduction In HAART Nave HIV Infected Adults In our Urban Population Kenya
The study was undertaken to explore and generate information on the morbidityrnpatterns in HAART Nave HIV infected adults on oral Cotrimoxazole prophylaxisCTXprnattending Mbagathi and Kenyatta National Hospitals comprehensive care centres.
A qualitative retrospective study design of mixed methods was used which comprisedrnClinical data extraction and Secondary data analysis of 450 personal medical records that existedrnand which met inclusion criteria based on age baseline CD4 cells 350 count non-pregnantrnabsence of active TB and on CTXp for duration of six months at the time of enrollment.
The study showed that patients in both Mbagathi district and Kenyatta National hospitalsrncomprehensive care centres CCC had at baseline CD4 cells range 350-600 and later at 12rnmonths CD4 cells range 400-1500. Patients of younger age when given CTXp had a consistentrnhigh CD4 cells count above 1000 CD4 cells count while those of older age had CD4 levels thatrnwere fluctuating. The median age was 31 years. In over 50 documentation common infectionsrnwere frequent and patients treated with essential antimicrobial drugs. We observed that CTXprnprophylaxis may have reduced severity of infections and this could also have supported up to 60rnof the resolved infections. The self-reported adherence to CTXp was observed as part of qualityrnmonitored care.
The findings of this study support work in a number of literature in other studies donernoutside Kenya on CTXp not associated with a worsened progression of HIV disease. Stockoutsrnshould be avoided due to public health implications. Further studies may be done to find out whatrnpotential CTXp has on HIV infected Kenyan patients with serious threat of bacterial infections inrnconjunction with the customized highly active antiretroviral therapy HAART.
Publication Information
Focus County(s):
Kisumu County
Programme Area(s):
Infectious and Parasitic Diseases
Public Health & Health Research Systems
Research Priority Area(s):
cancer (Breast, cervix, prostrate, throat, stomach, ovaries and skin)
Disease Domain(s):
Document History:
Publication Date: 01.Jan.2019
Conference Title: